Table 2.
Correlation between pMEK5 expression and clinicopathologic characteristics
| Variable | Cases | pMEK5 protein | P value | |
|---|---|---|---|---|
| Normal expression | Overexpression | |||
| Sex | 0.055 | |||
| Female | 158 | 79(50.0%) | 79(50.0%) | |
| Male | 177 | 70(39.5%) | 107(60.5%) | |
| Age at surgery, years | 0.835 | |||
| < 65 | 189 | 85(45.0%) | 104(55.0%) | |
| ≥ 65 | 146 | 64(43.8%) | 82(56.2%) | |
| Tumour location | 0.440 | |||
| Right colon | 57 | 21(36.8%) | 36(63.2%) | |
| Left colon | 99 | 45(44.5%) | 54(54.5%) | |
| Rectum | 179 | 83(46.4%) | 96(53.6%) | |
| pT (invasion depth) | 0.001 | |||
| T1+ T2 | 62 | 39(62.9%) | 23(37.1%) | |
| T3+ T4 | 273 | 110(40.3%) | 163(59.7%) | |
| pN (lymph node metastasis) | < 0.001 | |||
| N0 | 203 | 113(55.7%) | 90(44.3%) | |
| N1-N2 | 132 | 36(27.3%) | 96(72.7%) | |
| pM (distant metastasis) | < 0.001 | |||
| M0 | 305 | 146(47.9%) | 159(52.1%) | |
| M1 | 30 | 3(10.0%) | 27(90.0%) | |
| TNM stage | < 0.001 | |||
| I | 49 | 35(71.4%) | 14(28.6%) | |
| II | 145 | 78(53.8%) | 67(46.2%) | |
| III | 111 | 33(29.7%) | 78(70.3%) | |
| IV | 30 | 3(10.0%) | 27(90.0%) | |
| Differentiation grade | 0.074 | |||
| Well | 29 | 17(58.6%) | 12(41.4%) | |
| Moderate | 278 | 124(44.6%) | 154(55.4%) | |
| Poorly | 28 | 8(28.6%) | 20(71.4%) | |
| Preoperative CEA level | < 0.001 | |||
| < 5 ng/ml | 190 | 102(53.7%) | 88(46.3%) | |
| ≥ 5 ng/ml | 145 | 47(32.4%) | 98(67.6%) | |
| Preoperative CA19-9 level | 0.251 | |||
| < 60 U/ml | 296 | 135(45.6%) | 161(54.4%) | |
| ≥ 60 U/ml | 39 | 14(35.9%) | 25(64.1%) | |