Table 3.
Cox proportional hazards model univariate and multivariate analyses of individual parameters for correlations with disease-free survival (DFS)
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | CI(95%) | P value | HR | CI(95%) | P value | |
| Sex | ||||||
| Female | 1 | |||||
| Male | 0.966 | 0.662-1.409 | 0.856 | |||
| Age at surgery, years | ||||||
| < 65 | 1 | |||||
| ≥ 65 | 1.228 | 0.841-1.794 | 0.287 | |||
| Tumor location | ||||||
| Colon | 1 | 1 | ||||
| Rectum | 1.602 | 1.083-2.368 | 0.018 | 1.874 | 1.255-2.801 | 0.001 |
| TNM stage | ||||||
| I-II | 1 | 1 | ||||
| III-IV | 2.851 | 1.933-4.204 | < 0.001 | 2.383 | 1.572-3.614 | < 0.001 |
| pT (invasion depth) | ||||||
| T1-T2 | 1 | |||||
| T3-T4 | 1.398 | 0.822-2.379 | 0.216 | |||
| pN (lymph node metastasis) | ||||||
| N0 | 1 | |||||
| N1-N2 | 2.351 | 1.607-3.439 | < 0.001 | |||
| pM (distant metastasis) | ||||||
| M0 | 1 | |||||
| M1 | 7.250 | 4.619-11.38 | < 0.001 | |||
| Differentiation grade | ||||||
| Well and Moderate | 1 | 1 | ||||
| Poorly | 3.082 | 1.830-5.188 | < 0.001 | 2.988 | 1.746-5.114 | < 0.001 |
| Preoperative CEA level | ||||||
| < 5 ng/ml | 1 | 1 | ||||
| ≥ 5 ng/ml | 1.748 | 1.196-2.556 | 0.004 | 1.192 | 0.789-1.801 | 0.405 |
| Preoperative CA19-9 level | ||||||
| < 60 U/ml | 1 | 1 | ||||
| ≥ 60 U/ml | 1.926 | 1.146-3.236 | 0.013 | 1.779 | 1.035-3.056 | 0.037 |
| Phospho-MEK5 protein | ||||||
| Normal expression | 1 | 1 | ||||
| Overexpression | 1.898 | 1.264-2.850 | 0.002 | 1.388 | 0.900-2.141 | 0.139 |