Table 1. Cell type distribution of Math5 lineage descendants In wild-type Math5>Cre transgenic retinas.

	cells counted
	Math5 lineage	total	Math5 lineage (% of cell type)§	cell type† (% of retina)	Math5 lineage (% of retina)	cell type‡ (% of Math5 lineage)
CELL TYPE	(a)	(b)	(a/b) × 100	(c) × 100	(a/b)(c) × 100	(a/b)(c/f) × 100
RGC	700	1,265#	55§	0.6	0.3	11
cone	1,515	4,914	31	22	0.7	23
horizontal	1,041	3,592	23	0.5	0.2	5
amacrine	1,665	15,570*	11	7.9	0.8	29
INL	1,198	13,920*	9	7.0	0.6	20
displaced	467	1,648#	28	0.9	0.2	8
rod	2,085	173,000*	1	78.5	0.9	32
bipolar	12	12,900*	<0.1	7.4	<0.005	<0.2
Müller glia	5	8,800*	<0.1	2.9	<0.002	<0.1
TOTAL				100.0	2.9(f)	100

RGCs, displaced amacrines, and INL amacrines were counted in 33 fields (200×,8 eyes. 6 mice. R26floxGFP reporter). Horizontal cells were counted in 58 sections (8 eyes,6 mice, R26FLOXGFP reporter). All other cell types were counted in 50 to 70 fields (200X, 16 eyes, 12 mice, Z/AP reporter) Math5+ descendants detected using the Cre lineage system comprise 2.9% of the adult retina (f).

^*Estimated using cell type ratios reported by Jeon et al. (1998) for adult C57BL/6J mice. The total number of cones counted in surveyed fields was multplied by 35.2 to give the numberof rods, and by 3.32 for bipolar cells and 1.3 for muüller glia The total number of GCL neurons surveyed (RGC and displaced amacrines) was multiplied by 4.78 to estimate the number of inner nuclear layer (INL) amacrines.

^#RGCs (identified by retrograde axon labeling) represent 43% of GCL neurons (1265/2913 cells). The remaining GCL cells were scored as displaced amacrines.

^§Among n = 8 eyes, the mean RGC labeling fraction ±SEM was 54 ±2%, with a range between 46 and 63%. The overall labeling fraction for the GCL was 40% (1167/2913 cells), which represents 24% RGCs(700/2913 cells)and 16% displaced amacrines (467/2913 cells).

^†Calculated from Jeon et al. (1998) and shown in Fig 3I (left pie chart)

^‡These values are shown in Fig 3I (middle pie chart).