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. 2012 Jan 20;69(5):1229–1240. doi: 10.1007/s00280-011-1817-3

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© The Author(s) 2012

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Fig. 2 — a Serum trastuzumab emtansine (T-DM1) area under the concentration–time curve (AUC) by response in patients in studies TDM4374g and TDM4258g. b Serum T-DM1 maximum concentration (C _max) by response in patients in studies TDM4374g and TDM4258g. c Baseline circulating human epidermal growth factor receptor 2 (HER2) extracellular domain (ECD) by response in patients in studies TDM4374g and TDM4258g. d TT AUC_last by response in patients in studies TDM4374g and TDM4258g. AUC_last, area under the concentration–time curve in the last sample drawn; PD progressive disease, PR partial response, SD stable disease, TT total trastuzumab (T-DM1 plus unconjugated trastuzumab)