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Molecular heterogeneity in glioblastoma. (A) Immunohistochemistry for the mutant EGFR receptor EGFRvIII demonstrates a heterogeneous staining pattern within the tumor. Images from Nishikawa et al. (2004) used with permission. (B) Multicolor FISH reveals distinct subpopulations of either EGFR (red) or PDGFRA (green) amplification within a glioblastoma specimen. Images obtained from Cameron Brennan.
