Table 1.

Relative volume measurements (mean ± SD) of selected regions in the ITGβ3 KO compared to the corresponding WT.

Region	Relative volume (% total brain volume) mean ± SD		% Diff	FDR
	WT	ITGB3 KO
CORTICAL REGIONS
Entorhinal cortex	2.32 ± 0.10	2.50 ± 0.05	7.8	<0.001
Frontal lobe	8.78 ± 0.41	9.26 ± 0.20	5.5	<0.01
Parieto-temporal lobe	17.69 ± 0.36	18.65 ± 0.52	5.4	<0.001
Occipital lobe	1.60 ± 0.11	1.60 ± 0.06	NS	NS
SUBCORTICAL GRAY MATTER REGIONS
Amygdala	2.85 ± 0.10	3.05 ± 0.07	7.0	<0.001
Globus pallidus	0.63 ± 0.04	0.59 ± 0.02	−6.3	0.01
Hippocampus	4.62 ± 0.17	4.42 ± 0.07	−4.3	0.01
Dentate gyrus of the hippo.	0.87 ± 0.04	0.81 ± 0.02	−7.8	<0.001
Stratum granulosum of hippo.	0.22 ± 0.01	0.19 ± 0.01	−11.8	<0.001
Hypothalamus	2.17 ± 0.07	2.24 ± 0.07	3.5	0.04
Medulla	5.55 ± 0.19	5.33 ± 0.19	−4.1	0.03
Midbrain	2.82 ± 0.10	2.80 ± 0.06	NS	NS
Periaqueductal gray matter†	0.85 ± 0.04	0.86 ± 0.03	NS	NS
Striatum	4.74 ± 0.13	4.56 ± 0.08	−3.7	0.01
Thalamus	3.66 ± 0.14	3.67 ± 0.06	NS	NS
CEREBELLAR REGIONS
Arbor vita of the cerebellum‡	2.25 ± 0.07	1.96 ± 0.03	−12.8	<0.001
Cerebellar cortex	11.05 ± 0.54	10.05 ± 0.34	−9.0	<0.001
WHITE MATTER REGIONS
Anterior commisure – anterior	0.29 ± 0.02	0.29 ± 0.01	NS	NS
Anterior commisure – posterior	0.10 ± 0.01	0.10 ± 0.00	NS	NS
Corpus callosum	3.50 ± 0.08	3.25 ± 0.09	−7.1	<0.001
Cerebral peduncle	0.46 ± 0.02	0.43 ± 0.01	−5.5	0.01
Fimbria	0.70 ± 0.06	0.62 ± 0.03	−12.3	0.001
Fornix	0.15 ± 0.01	0.14 ± 0.00	−4.7	0.01
Internal capsule	0.58 ± 0.03	0.53 ± 0.02	−9.5	<0.001

Percent difference is also listed when significant with the corresponding False Discovery Rate (FDR).

^†The periaqueductal gray matter includes the raphe nuclei.

^‡The arbor vita of the cerebellum includes the deep cerebellar nuclei.