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. 2012 Apr 1;2(4):499–504. doi: 10.1534/g3.112.002196

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Copyright © 2012 Rutschmann et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The woodrat mutation affects coat color in both a cell-autonomous and systemic manner. (A) The woodrat coat color phenotype at 8 days (1), 15 days (2), 18 days (3), and 6 weeks of age (4). (B) Chromosome 8 genes encompassed by the BAC used for transgenesis. (C) Relative expression of Mitf mRNA measured in the skin of wild type and Mbtps1^wrt/wrt mice by reverse transcription PCR. (D) Skin grafted from a C57BL/6J (B6) mouse onto a Mbtps1^wrt/wrt mouse and from a Mbtps1^wrt/wrt mouse onto a C57BL/6J mouse on the days indicated posttransplantation. Results are representative of 3 (wrt/wrt→C57BL/6J) transplants and 3 (C57BL/6J→wrt/wrt) transplants. (E) Skin grafted from a Tyr^c-ghost homozygous mutant mouse onto a wild-type C57BL/6J mouse and from a wild-type C57BL/6J mouse onto a Tyr^c-ghost homozygote.