Table 2.
Neonatal outcomes in the study groups compared with the reference group.
| Outcome n |
Ref. group 26 870 | ART 255 |
Anovulation 68 | Endometriosis 49 | Male factor 43 |
Tubal factor 38 |
PCOS 27 |
Unexplained 30 |
|---|---|---|---|---|---|---|---|---|
| Preterm birth | ||||||||
| % | 6.3 | 12.7 | 13.4 | 18.6 | 9.8 | 10.5 | 14.8 | 6.7 |
| P-value | <0.0001 | <0.05 | <0.005 | NS | NS | NS | NS | |
| OR | 2.17 | 2.33 | 3.43 | 1.62 | 1.77 | 2.61 | 1.07 | |
| 95% CI | 1.48–3.17 | 1.15–4.71 | 1.59–7.42 | 0.58–4.53 | 0.63–4.99 | 0.90–7.57 | 0.26–4.51 | |
| AOR | 2.12 | 2.07 | 3.25 | 1.80 | 1.71 | 2.85 | 1.06 | |
| 95% CI | 1.44–3.11 | 1.01–4.23 | 1.50–7.07 | 0.64–5.11 | 0.60–4.85 | 0.98–8.30 | 0.25–4.48 | |
|
| ||||||||
| LBW | ||||||||
| % | 4.7 | 8.7 | 7.4 | 10.2 | 9.3 | 10.5 | 3.7 | 10.0 |
| P-value | <0.005 | NS | NS | NS | NS | NS | NS | |
| OR | 1.93 | 1.62 | 2.32 | 2.09 | 2.40 | 0.79 | 2.27 | |
| 95% CI | 1.24–3.00 | 0.65–4.04 | 0.92–5.86 | 0.75–5.87 | 0.85–6.79 | 0.11–5.79 | 0.69–7.49 | |
| AOR | 1.83 | 1.35 | 2.13 | 2.27 | 2.33 | 0.87 | 2.18 | |
| 95% CI | 1.17–2.86 | 0.54–3.40 | 0.84–5.41 | 0.80–6.42 | 0.82–6.63 | 0.12–6.49 | 0.65–7.24 | |
|
| ||||||||
| SGA | ||||||||
| % | 9.7 | 12.4 | 11.8 | 6.3 | 19.1 | 7.9 | 7.4 | 23.3 |
| P-value | NS | NS | NS | NS | NS | NS | <0.05 | |
| OR | 1.30 | 1.24 | 0.62 | 2.18 | 0.80 | 0.74 | 2.83 | |
| 95% CI | 0.90–1.90 | 0.59–2.59 | 0.19–1.20 | 1.01–4.72 | 0.24–2.59 | 0.18–3.14 | 1.21–6.59 | |
| AOR | 1.08 | 1.02 | 0.49 | 1.78 | 0.69 | 0.78 | 2.29 | |
| 95% CI | 0.73–1.59 | 0.49–2.16 | 0.15–1.59 | 0.78–4.06 | 0.21–2.25 | 0.18–3.33 | 0.97–5.41 | |
|
| ||||||||
| NICU admiss | ||||||||
| % | 9.5 | 16.6 | 14.7 | 18.4 | 20.9 | 15.8 | 18.5 | 10.0 |
| P-value | <0.0005 | NS | <0.05 | <0.05 | NS | NS | NS | |
| OR | 1.87 | 1.64 | 2.14 | 2.51 | 1.78 | 2.16 | 1.05 | |
| 95% CI | 1.34–2.60 | 0.84–3.21 | 1.04–4.01 | 1.20–5.24 | 0.74–4.26 | 0.82–5.70 | 0.32–3.48 | |
| AOR | 1.64 | 1.32 | 1.78 | 2.49 | 1.62 | 1.98 | 0.92 | |
| 95% CI | 1.17–2.30 | 0.67–2.60 | 0.86–3.68 | 1.18–5.26 | 0.67–3.90 | 0.74–5.28 | 0.28–3.05 | |
Preterm birth <37 gestational weeks, LBW: low birth weight (<2500 g), SGA: small for gestational age (fetal indexes < the 10th percentile adjusted for Finnish population), NICU: neonatal intensive care unit.
AOR: OR adjusted for age, parity, BMI, smoking, previous foetal deaths and miscarriages, chronic illness, and marital status.