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The t(X;17)(p11;25) translocation. (a) The ASPSCR-1 gene is located at chromosome 17q25 and the TFE3 gene at Xp11. The breakpoint found in the ASPSCR-1 gene is marked at “1”, and the two defined breakpoints in the TFE3 gene are marked “2” and “3”. (b) Following translocation, two variants of the ASPSCR-1-TFE3 fusion gene can be created. The Type 1 translocation retains the N-terminal activation domain of the TFE3 gene.
