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. Author manuscript; available in PMC: 2012 Apr 26.
Published in final edited form as: Genet Med. 2008 Nov;10(11):797–804. doi: 10.1097/GIM.0b013e318187e106

Figure 1.

Figure 1

Genetic screening strategy for small families segregating ADSNHL. AudioGene is used to rank order all known genes that cause ADSNHL (letters in black boxes), placing genes that have similar audioprofiles into clusters (red boxes). Haplotyping is used to determine whether any candidate gene within a given cluster can be eliminated; mutation screening is completed on candidate genes that cannot be eliminated. If families are too small to make haplotyping useful, all genes within a cluster will be screened, beginning with the highest ranking cluster.