Table 3.
Heritability estimates for baseline blood pressure and blood pressure response to the Cold Pressor Test
Trait* | Heritability Estimate (Standard Error) | P value | % of variance explained by
|
|
---|---|---|---|---|
Measured Covariates* | Additive Genetic Effects | |||
Systolic blood pressure | ||||
Baseline | 0.27 (0.08) | < 0.0001 | 26 | 20 |
Response (iAUC): | ||||
Reactivity (0 – 2 min.) | 0.15 (0.07) | 0.005 | 14 | 13 |
Recovery (2 – 5 min.) | 0.14 (0.06) | 0.006 | 15 | 12 |
Diastolic blood pressure | ||||
Baseline | 0.21 (0.08) | 0.0008 | 23 | 17 |
Response (iAUC): | ||||
Reactivity (0 – 2 min.) | 0.27 (0.08) | < 0.0001 | 5 | 25 |
Recovery (2 – 5 min.) | 0.20 (0.07) | 0.0003 | 10 | 18 |
iAUC = incremental Area Under the Curve
Adjusted for age, age2, sex, age- and age2-by-sex interactions, body mass index, resting heart rate, and for response phenotypes only the baseline blood pressure.