Table 4.
Changes in gene expression induced by knockdown of ZEB1, ZEB2, or both in NSCLC cell lines.
| siRNA | ZEB1 | ZEB2 | E-cad | EpCAM | ESRP1 | ESRP2 | CDS1 | ST14 | FGFR1 | Vimentin | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| H157 | ZEB1 | 0.23 | 2.1 | 2.5 | 0.79 | 3.4 | 2.3 | 1.7 | 7.1 | 3.7 | 0.94 |
| ZEB2 | 0.72 | 0.10 | 0.20 | 1.4 | 2.2 | 4.8 | 0.29 | 1.4 | 1.5 | 1.2 | |
| ZEB1 + ZEB2 | 0.36 | 0.15 | 18 | 74 | 164 | 3.7 | 7.3 | 16 | 2.5 | 0.8 | |
| H460 | ZEB1 | 0.27 | 1.0 | 179 | 20 | 1.9 | 1.3 | 4.2 | 3.8 | 1.8 | 1.2 |
| ZEB2 | 1.0 | 0.21 | 0.65 | 1.7 | 0.85 | 1.8 | 1.3 | 1.2 | 1.2 | 1.5 | |
| ZEB1 + ZEB2 | 0.33 | 0.25 | 2280 | 139 | 4.5 | 2.5 | 10 | 12 | 2.7 | 1.9 | |
| H661 | ZEB1 | 0.25 | 1.1 | 3.7 | 1.6 | 1.1 | 0.86 | 2.1 | 1.5 | 1.0 | 0.85 |
| ZEB2 | 1.4 | 0.18 | 1.9 | 1.7 | 2.0 | 1.4 | 1.7 | 0.53 | 1.2 | 1.0 | |
| ZEB1 + ZEB2 | 0.41 | 0.33 | 32 | 3.4 | 6.2 | 1.4 | 3.8 | 0.38 | 1.7 | 1.3 | |
| A549 | ZEB1 | 0.27 | 0.16 | 1.6 | 4.0 | 2.5 | 0.86 | 2.4 | 2.4 | 0.29 | 0.36 |
| ZEB2 | 0.68 | 0.06 | 0.49 | 0.74 | 0.62 | 0.33 | 0.76 | 1.4 | 0.47 | 0.53 | |
| ZEB1 + ZEB2 | 0.26 | 0.11 | 2.5 | 2.6 | 4.2 | 0.32 | 2.5 | 1.4 | 0.69 | 0.59 | |