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. Author manuscript; available in PMC: 2013 Jan 1.

Published in final edited form as: Bioorg Med Chem Lett. 2011 Oct 28;22(1):601–605. doi: 10.1016/j.bmcl.2011.10.074

Scheme 1 — Reagents and conditions: (a) EDC, CH₂Cl₂, rt, 24 h, 68%; (b) TFA, CH₂Cl₂, rt, 24 h, 89%; (c) 2,4,6-trimethylbenzoyl chloride, Et₃N, CH₂Cl₂, rt, 24 h, 85%; (d) mesitaldehyde, NaBH(OAc)₃, CH₂Cl₂, rt, 12 h, 82%; (e) R-SO₂Cl, Et₃N, CH₂Cl₂, rt, 24 h, 70–91%; (f) R′OCl, Et₃N, CH₂Cl₂, rt, 24 h, 85–92%.