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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Anesthesiology. 2011 Sep;115(3):531–540. doi: 10.1097/ALN.0b013e31822a2316

Figure 6.

Figure 6

Effect of isoflurane (Iso) on mitochondrial respiration using substrates pyruvate/malate (P/M), succinate (Succ), and adenosine diphosphate (ADP) in the absence or presence of Iso. Representative traces demonstrate the effect of Iso on oxygen consumption using P/M (A), Succ (B) and Succ+rotenone (C). Iso decreased mitochondrial respiration compared to the control group (Con) when P/M were used (D). When Succ was used in the absence of rotenone, Iso significantly increased mitochondrial respiration (E). Iso had no significant effect on mitochondrial respiration when Succ was used in the presence of rotenone (F). Summary data are mean±SD. P/M; n=10/group. Succinate and Succinate+Rotenone; n=8/group. *P<0.05 versus Con.