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. Author manuscript; available in PMC: 2013 Apr 20.
Published in final edited form as: Org Lett. 2012 Apr 3;14(8):2110–2113. doi: 10.1021/ol300647k

Table 1.

Optimization of alkylation conditions

graphic file with name nihms368447t1.jpg
entry conditions result
1 KHMDS (2 equiv), THF, −78 °C to rt decomposition
2 KHMDS (1.1 equiv), THF, −78 °C to rt 14 (38–84%)
3 KHMDS (1.1 equiv), TBAI (1 equiv) THF/NEt3, −78 °C to rt 14 (74%)