Table 2.

Uteroplacental evaluation in non-pregnant and pregnant mice

Cardiac Parameters	Not pregnant (n=6)	P*	Embryonic Day 7 (n=6)	Embryonic Day 13 (n=6)	Embryonic Day 18 (n=6)	P**
Fetal Heart Rate (beats/min)				146.5 (105.0–171.0)	193.0 (127.0–216.0)	0.001
Umbilical Artery
Resistive index				0.9 (0.9–10)	0.9 (0.9–0.9)	0.25
Peak systolic velocity (mm/s)				52.4 (23.8–77.8)	84.3 (65.4–132.0)	<0.001
End diastolic velocity (mm/s)				4.8 (2.1–7.3)	7.0 (3.2–10.9)	0.015
Systolic/diastolic ratio				11.9 (7.6–23.0)	14.8 (8.9–18.4)	0.33
Uterine Artery
Resistive index	0.7 (0.7–0.9)	0.59	0.7 (0.6–0.7)	0.5 (0.4–0.7)	0.6 (0.6–0.7)	0.11
Peak systolic velocity (mm/s)	147.0 (23.4–280.4)	0.94	110.5 (72.2–239.2)	105.7 (43.7–318.4)	152.3 (87.4–209.1)	0.51
End diastolic velocity (mm/s)	26.3 (7.7–92.6)	0.31	34.8 (28.2–64.6)	51.4 (14.9–175.8)	56.4 (30.9–73.6)	0.51
Velocity Time Interval (mm)	22.9 (2.7–31.4)	0.82	15.5 (11.7–26.3)	13.5 (5.9–39.0)	16.0 (9.6–22.5)	0.31
Pulsatility index	1.1 (1.1–1.8)	0.39	1.2 (0.9–1.5)	0.7 (0.5–1.2)	1.1 (0.9–1.2)	0.11
Systolic/diastolic ratio	3.2 (2.9–10.0)	0.33	3.1 (2.3–3.6)	2.0 (1.6–3.4)	2.8 (2.5–3.3)	0.11
Placental volume (mm3)				92.8 (65.1–114.2)	166.8 (132.7–244.1)	0.03

Data are presented as median (10^th–90^th percentiles)

^*Exact Wilcoxon test

^**Friedman test for embryonic days 7, 13 and 18; Wilcoxon signed rank for embryonic days 13 and 18.