Table 1.

Training-induced improvement in maximal endurance time in PGC-1α KO and aged rats

	Untrained	Trained	Untrained	Trained
Endurance capacity (min)a	Young rats		Aged rats
Before	36.8 ± 4.6	42.0 ± 12.1	13.2 ± 4.8	14.7 ± 5.8
After 3 weeks	38.5 ± 4.0	115.7 ± 18.2*, **	19.7 ± 7.5	46.3 ± 6.5*, **
Endurance capacity (min)b	Wild-type mice		PGC-1α KO mice
Before	37.0 ± 24.5	39.3 ± 26.2	12.0 ± 6.9	13.2 ± 8.8
After 4 weeks	41.3 ± 27.8	158.8 ± 53.3***, ****,*****	21.2 ± 3.6	58.0 ± 16.4***, ****

^aMeans (±SD) results of maximal endurance time before and after endurance training in young and aged rats. Twenty-four male Wistar rats were randomly divided into four experimental groups: young untrained (n = 6), young trained (n = 6), aged untrained (n = 6), and aged trained (n = 6)

^bMeans (±SD) results of maximal endurance time before and after endurance training in WT and PGC-1α KO mice. Twenty-seven male mice were randomly divided into four experimental groups: WT untrained (n = 6), WT trained (n = 8), KO untrained (n = 7), and KO trained (n = 6)

*p < 0.05 when compared to values before training

**p < 0.05 when compared to untrained groups

***p < 0.05 when compared to values before training

****p < 0.05 when compared to the untrained group

*****p < 0.05 when compared to the KO trained mice