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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: J Cell Biochem. 2012 Apr;113(4):1159–1169. doi: 10.1002/jcb.23451

Figure 7. Schematic representation of Hcy-induced mechanism of increased endothelial cell layer permeability.

Figure 7

Hcy, through activation of MMP-9, affects transcellular transport by increasing the caveolae formation and paracellular transport by disrupting tight junction-associated protein ZO-1, adherence junction protein, VE-cadherin, and increases formation of F-actin that further causes cellular retraction.