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. Author manuscript; available in PMC: 2013 May 8.
Published in final edited form as: Oncogene. 2012 Jan 23;31(45):4750–4758. doi: 10.1038/onc.2011.633

Figure 4. CXCR7 in the primary tumor microenvironment increases growth and metastasis of breast cancer cells expressing CXCR4.

Figure 4

Mice were implanted with orthotopic breast tumor xenografts comprised of human mammary fibroblasts expressing CXCL12-GL (HMF-CXCL12-GL) and 231-CXCR4-FL cells combined with either 231-CXCR7 or 231-control cells (n = 10 per group). A) Mean values + SEM for firefly luciferase bioluminescence after 4 weeks of tumor growth from 231-CXCR4-FL cells in mice with either 231-control or 231-CXCR7 scavenger cells. B) Mean values for weights of excised tumors from each group of mice. C) Representative firefly luciferase bioluminescence images of metastases from 231-CXCR4-FL cells in a mouse from each group. Scale bar shows pseudocolor display for photon flux with red and blue representing highest and lowest values, respectively. D) Quantified data for 231-CXCR4-FL bioluminescence in metastatic sites for mice with either 231-control or 231-CXCR7 scavenger cells. Data were presented as mean values + SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.005.