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. Author manuscript; available in PMC: 2013 May 8.
Published in final edited form as: Oncogene. 2012 Jan 23;31(45):4750–4758. doi: 10.1038/onc.2011.633

Figure 6. CXCR7 regulates cell surface expression of CXCR4 and CXCL12-dependent signaling.

Figure 6

A) Flow cytometry plots for expression of cell surface CXCR4 in 231-CXCR4 cells cultured for 2 days in serum-free medium alone (control), 100 ng/ml CXCL12 (CXCL12), 100 ng/ml CXCL12 plus co-cultured 231-control cells (CXCL12, 231-control), or 100 ng/ml CXCL12 plus co-cultured 231-CXCR7 cells (CXCL12, 231-CXCR7). Black line, unstained cells; gray line, isotype antibody; dashed line, CXCR4 antibody. B) Graph displays mean fluorescence intensity for cell surface CXCR4 from flow cytometry.