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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Anesthesiology. 2012 May;116(5):1116–1123. doi: 10.1097/ALN.0b013e3182518be3

Figure 4. Effects of cocaine on responding for electrical stimulation of the paraventricular nucleus of the hypothalamus (PVN) and medial forebrain bundle (MFB) for control and spinal nerve-ligated (SNL) rats.

Figure 4

(A) Reduction in EF50 (frequency at which rats emitted 50% of maximal responding) was calculated by subtracting the EF50 for the two (PVN) and three (MFB) components following drug injection from the EF50 for the two components preceding drug injection. Data shown are averages across control (n=8 and n=7 for 5 and 10mg/kg, respectively) and SNL (n=9 and n=12 for 5 and 10mg/kg, respectively) rats with PVN electrodes, as well as control (n=7), and SNL (n=8 and n=9 for 5 and 10mg/kg, respectively) rats with MFB electrodes. Frequency-response curves before and after 5mg/kg morphine (30-min) are shown for SNL rats with PVN (B, n=9) and MFB (C, n=8) electrodes. * Significantly different from saline treatment P ≤ 0.05.