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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Alcohol Clin Exp Res. 2012 Jan 24;36(7):1139–1147. doi: 10.1111/j.1530-0277.2011.01720.x

Figure 2.

Figure 2

Ethanol-induced inflammation and liver injury markers in mouse livers. A) C57BL/6J wild-type (WT) and Bid-deficient mice were allowed free access to diets with increasing concentrations of ethanol or pair-fed controls. B) WT mice were gavaged daily with VX166 (10mg/kg) or vehicle during the ethanol feeding protocol (25d, 32%). Paraffin-embedded liver sections were stained with H & E. A,B) Histological scoring for inflammation was carried out by an experienced pathologist using a scale of 0 to 3. ALT and AST activities were measured in plasma. Values represent means ± SEM, n=4–6. Values with different alphabetical superscripts were significantly different from each other, p< 0.05. ND = not detected.