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. 2012 Apr 24;3:791. doi: 10.1038/ncomms1795

Figure 1. Advillin and Wnt1 Cre expression pattern and pain behaviour of Advillin-Cre mice.

Figure 1

(a,b) Expression pattern of Cre activity. Arrow: trigeminal, arrowhead: DRG (scale bar 1 mm). X-gal staining of Advillin-Cre positive (c) DRG and (d) SCG sections, and Wnt1-Cre positive (e) DRG and (f) SCG sections (scale bar 100 μm). Acute nociceptive responses of heterozygous Advillin-Cre (orange columns) and littermate (white columns) mice (N shown as littermate/AdCre+/−). (g) Motor coordination: Rotarod test (N=15/16). (h) Light touch: von Frey (N=15/16). (i) Mechanical pain: Randall–Selitto test (N=13/16). (j) Thermal spinal reflex: Hargreaves' test (N=15/16). (k) Noxious cooling: acetone test (N=10/11). (l) Supraspinal thermal: hotplate test at 50 and 55 °C (N=6/6). All behavioural data analysed by t-test. Results are presented as mean±s.e.m.