Figure 6. Behavioural responses of Nav1.7^Advill and Nav1.7^Wnt1 mice following L5 SNT.

(a) Mechanical sensitization following L5 SNT of Nav1.7^Advill (red boxes, N=6) and littermate (white boxes, N=9) mice. (b) Mechanical sensitization following L5 SNT of Nav1.7^Wnt1 (green boxes, N=9) and littermate (white boxes, N=12) mice. (c) Mechanical sensitization in littermate mice treated with 6-OHDA (purple column, N=6) or vehicle (white column, N=6) 28 days after L5 SNT surgery. All analysed by two-way analysis of variance followed by the Bonferroni post hoc test. Results are presented as mean±s.e.m. *P<0.05, **P<0.01 and ***P<0.001 (individual points).