FIG. 1.

Temporal evolution of CMTs constructed in 0.5 mg/mL fibrin and 1.0 mg/mL collagen gels and tethered to rigid (k=0.45 μN/μm) cantilevers. (A) Representative images depicting the time course of a contracting CMT. (B) Representative recording of the tension as a function of the time of a CMT on day 5. (C) Temporal evolution of the spontaneous beating frequency and (D) of the contraction duration of beating (contraction and relaxation). Data are the average of 15 CMTs±SEM. *p<0.01. CMT, cardiac microtissue.