Table 3.

Multivariable determinants of post year 1 major cardiovascular events (MCVE)

Risk factors	Major cardiovascular events	χ2 Statistics^*	P- value^*
Risk factors	Hazard Ratio (95% CI) ^*	χ2 Statistics^*	P- value^*
Basic model
Treatment (Atorvastatin 80 mg)	0.82 (0.70, 0.94)	7.43	0.006
Age (years): per 1SD	1.13 (1.04, 1.23)	8.04	0.005
Men	1.33 (1.07, 1.65)	6.69	0.01
Smoking
Current	1.65 (1.28, 2.12)	15.35	<0.001
Previous	1.00 (0.82, 1.20)	0.01	0.96
Never	1.00	------	------
Hypertension	1.38 (1.17, 1.63)	14.51	<0.001
Diabetes	1.33 (1.11, 1.60)	9.48	0.002

Variables selected by forward stepwise elimination
Body mass index(kg/m²): per 1SD	1.09 (1.02, 1.17)	6.34	0.01
Myocardial infarction	1.60 (1.36, 1.87)	32.79	<0.001
Angina	1.36 (1.10, 1.68)	8.16	0.004
Cerebrovascular disease	1.73 (1.36, 2.19)	19.80	<0.001
Peripheral vascular disease	1.32 (1.09, 1.61)	7.84	0.005
Congestive heart failure	1.54 (1.24, 1.90)	15.59	<0.001
Coronary revascularization: Bypass	1.26 (1.08, 1.47)	8.44	0.004
Baseline apolipoprotein A-I (mg/dL): per 1SD	0.91 (0.84, 0.99)	5.23	0.02
Baseline apolipoprotein B (mg/dL): per 1SD	1.19 (1.11, 1.28)	21.87	<0.001
Use of calcium channel blockers	1.31 (1.12, 1.54)	10.99	<0.001
Use of aspirin	0.67 (0.56, 0.81)	17.31	<0.001
Baseline blood urea nitrogen (mg/dL): per 1SD	1.10 (1.03, 1.17)	8.92	0.003

Hazard ratios, 95% confidence intervals (CIs), and p-values are based on multivariable Cox proportional hazard analysis forcing age, gender, smoking, hypertension, and diabetes in the model; and the remaining significant (p< 0.10) variables identified from the univariable analyses were entered into the model by forward stepwise selection process with a critical value of 0.05. Hazard ratios and the corresponding 95% CIs are calculated based on 1 standard deviation (SD) increase for the continuous variables.