Table 2.
Risk of first CVD event or death for on-treatment lipids, apolipoproteins, and ratios by tertiles
| Tertile 1 | Tertile 2 | Tertile 3 | P for linear trend | |
|---|---|---|---|---|
| Lipids | ||||
| Total cholesterol, mg/dL | <123 | 123–145 | >145 | |
| No. CVD/No. CVD or death/Total N | 37/60/2726 | 22/36/2498 | 42/69/2608 | |
| CVD Incidence Rate | 0.60 | 0.40 | 0.78 | |
| CVD HRadjusted (95% CI) | 1.00 | 0.75 (0.44–1.28) | 1.53 (0.96–2.45) | 0.04 |
| CVD/death HRadjusted (95% CI) | 1.00 | 0.72 (0.47–1.09) | 1.47 (1.02–2.11) | 0.02 |
| LDL cholesterol, mg/dL | <48 | 48–64 | >64 | |
| No. CVD/No. CVD or death/Total N | 30/53/2628 | 23/40/2618 | 48/72/2586 | |
| CVD Incidence Rate | 0.51 | 0.39 | 0.91 | |
| CVD HRadjusted (95% CI) | 1.00 | 0.83 (0.48–1.43) | 1.99 (1.25–3.19) | 0.0007 |
| CVD/death HRadjusted (95% CI) | 1.00 | 0.78 (0.52–1.18) | 1.63 (1.13–2.34) | 0.002 |
| Non-HDL cholesterol, mg/dL | <69 | 69–88 | >88 | |
| No. CVD/No. CVD or death/Total N | 31/52/2713 | 31/46/2595 | 39/67/2524 | |
| CVD Incidence Rate | 0.52 | 0.53 | 0.75 | |
| CVD HRadjusted (95% CI) | 1.00 | 1.11 (0.67–1.84) | 1.64 (1.01–2.66) | 0.03 |
| CVD/death HRadjusted (95% CI) | 1.00 | 0.98 (0.66–1.46) | 1.72 (1.19–2.48) | 0.001 |
| Triglycerides, mg/dL | <83 | 83–121 | >121 | |
| No. CVD/No. CVD or death/Total N | 35/53/2663 | 30/52/2581 | 36/60/2588 | |
| CVD Incidence Rate | 0.61 | 0.54 | 0.62 | |
| CVD HRadjusted (95% CI) | 1.00 | 0.94 (0.58–1.55) | 1.06 (0.65–1.73) | 0.76 |
| CVD/death HRadjusted (95% CI) | 1.00 | 1.12 (0.76–1.66) | 1.31 (0.89–1.93) | 0.16 |
| HDL cholesterol, mg/dL | <47 | 47–59 | >59 | |
| No. CVD/No. CVD or death/Total N | 41/67/2770 | 27/48/2522 | 33/50/2540 | |
| CVD Incidence Rate | 0.66 | 0.50 | 0.60 | |
| CVD HRadjusted (95% CI) | 1.00 | 0.80 (0.48–1.33) | 1.04 (0.63–1.71) | 0.84 |
| CVD/death HRadjusted (95% CI) | 1.00 | 0.85 (0.56–1.24) | 0.83 (0.56–1.23) | 0.36 |
| Apolipoproteins | ||||
| Apolipoprotein A-1, mg/dL | <152 | 152–179 | >179 | |
| No. CVD/No. CVD or death/Total N | 36/64/2612 | 40/62/2649 | 25/39/2571 | |
| CVD Incidence Rate | 0.64 | 0.69 | 0.44 | |
| CVD HRadjusted (95% CI) | 1.00 | 1.06 (0.66–1.68) | 0.76 (0.44–1.30) | 0.33 |
| CVD/death HRadjusted (95% CI) | 1.00 | 0.92 (0.64–1.31) | 0.59 (0.39–0.90) | 0.01 |
| Apolipoprotein B, mg/dL | <60 | 60–75 | >75 | |
| No. CVD/No. CVD or death/Total N | 29/48/2660 | 30/46/2628 | 42/71/2544 | |
| CVD Incidence Rate | 0.50 | 0.50 | 0.78 | |
| CVD HRadjusted (95% CI) | 1.00 | 1.01 (0.60–1.68) | 1.60 (0.98–2.59) | 0.04 |
| CVD/death HRadjusted (95% CI) | 1.00 | 0.91 (0.61–1.37) | 1.64 (1.13–2.38) | 0.003 |
| Ratios | ||||
| Total/HDL cholesterol | <2.23 | 2.23–2.83 | >2.83 | |
| No. CVD/No. CVD or death/Total N | 31/48/2613 | 32/49/2613 | 38/68/2606 | |
| CVD Incidence Rate | 0.54 | 0.55 | 0.68 | |
| CVD HRadjusted (95% CI) | 1.00 | 1.04 (0.63–1.73) | 1.27 (0.77–2.10) | 0.31 |
| CVD/death HRadjusted (95% CI) | 1.00 | 1.10 (0.73–1.65) | 1.63 (1.11–2.39) | 0.008 |
| LDL/HDL cholesterol | <0.87 | 0.87–1.29 | >1.29 | |
| No. CVD/No. CVD or death/Total N | 25/45/2611 | 33/54/2611 | 43/66/2610 | |
| CVD Incidence Rate | 0.43 | 0.56 | 0.79 | |
| CVD HRadjusted (95% CI) | 1.00 | 1.20 (0.70–2.03) | 1.82 (1.10–3.02) | 0.01 |
| CVD/death HRadjusted (95% CI) | 1.00 | 1.15 (0.77–1.73) | 1.64 (1.11–2.42) | 0.008 |
| Apolipoprotein B/A-1 | <0.35 | 0.35–0.47 | >0.47 | |
| No. CVD/No. CVD or death/Total N | 25/42/2611 | 29/42/2611 | 47/81/2610 | |
| CVD Incidence Rate | 0.43 | 0.49 | 0.86 | |
| CVD HRadjusted (95% CI) | 1.00 | 1.15 (0.66–1.98) | 1.96 (1.18–3.25) | 0.004 |
| CVD/death HRadjusted (95% CI) | 1.00 | 1.02 (0.66–1.57) | 2.12 (1.44–3.12) | <0.0001 |
Incidence rates are per 100 person-years. Hazard ratios were adjusted for sex, age, smoking status, family history of premature atherosclerosis, body mass index, systolic blood pressure, and fasting glucose.