Table 1.

Significant loci at P<5×10⁻⁰⁸ in combined GWAS and candidate SNP meta-analysis

Locus	Chr	Index SNP	Coded/Non-coded Allele	AF	GWAS β	GWAS SEGC	GWAS PGC	I2	Prevend β	Prevend P	POverall	Multi SNP β	Multi SNP P	Nearest Gene	SNP Annotation
1	3	rs6801957	T/C	0.41	0.77	0.07	1.10×10−28	45.3	-	-	1.10×10−28	0.54	3.43×10−14	SCN10A	intron
	3	rs9851724	C/T	0.33	−0.66	0.07	1.91×10−20	57.1	-	-	1.91×10−20	−0.60	5.78×10−16	SCN10A/SCN5A	intergenic
	3	rs10865879	T/C	0.41	0.77	0.07	1.10×10−28	53.6	-	-	1.10×10−28	0.33	1.67×10−04	SCN5A/EXOG	intergenic
	3	rs11710077	T/A	0.21	−0.84	0.09	5.74×10−22	23.8	-	-	5.74×10−22	−0.44	1.33×10−06	SCN5A	intron
	3	rs11708996	C/G	0.16	0.79	0.10	1.26×10−16	0.0	-	-	1.26×10−16	0.47	7.23×10−06	SCN5A	intron
	3	rs2051211	G/A	0.26	−0.44	0.08	1.57×10−08	0.0	-	-	1.57×10−08	−0.18	3.71×10−02	EXOG	intron
2	6	rs9470361	A/G	0.25	0.87	0.08	3.00×10−27	14.6	-	-	3.00×10−27	-	-	CDKN1A	intergenic
3	6	rs11153730	C/T	0.49	0.59	0.07	1.26×10−18	5.3	-	-	1.26×10−18	-	-	C6orf204/SLC35F1/PLN/BRD7P3	intergenic
4	1	rs9436640	G/T	0.46	−0.59	0.07	4.57×10−18	51.2	-	-	4.57×10−18	-	-	NFIA	intron
5	5	rs13165478	A/G	0.36	−0.55	0.07	7.36×10−14	64.6	-	-	7.36×10−14	-	-	HAND1/SAP30L	intergenic
6	7	rs1362212	A/G	0.18	0.69	0.09	1.12×10−13	0.0	-	-	1.12×10−13	-	-	TBX20	intergenic
7	14	rs11848785	G/A	0.27	−0.50	0.08	1.04×10−10	0.0	-	-	1.04×10−10	-	-	SIPA1L1	intron
8	12	rs883079	C/T	0.29	0.49	0.08	1.33×10−10	8.3	-	-	1.33×10−10	-	-	TBX5	3′-UTR
9	12	rs10850409	A/G	0.27	−0.49	0.08	3.06×10−10	0.0	-	-	3.06×10−10	-	-	TBX3	intergenic
10	10	rs7342028	T/G	0.27	0.48	0.08	4.95×10−10	0.0	-	-	4.95×10−10	-	-	VTI1A	intron
11	18	rs991014	T/C	0.42	0.42	0.07	6.20×10−10	0.0	-	-	6.20×10−10	-	-	SETBP1	intron
12	2	rs17020136	C/T	0.21	0.51	0.08	1.90×10−9	0.0	-	-	1.90×10−9	-	-	HEATR5B/STRN	intron
13	3	rs4687718	A/G	0.14	−0.63	0.11	6.25×10−9	0.0	-	-	6.25×10−9	-	-	TKT/PRKCD/CACNA1D	intron
14	2	rs7562790	G/T	0.40	0.39	0.07	8.22×10−9	0.0	-	-	8.22×10−9	-	-	CRIM1	intron
15	1	rs17391905	G/T	0.05	−1.35	0.23	8.72×10−9	4.0	-1.17	0.005	3.26×10−10	-	-	C1orf185/RNF11/CDKN2C/FAF1	intergenic
16	17	rs9912468	G/C	0.43	0.39	0.07	1.06×10−8	28.2	-	-	1.06×10−8	-	-	PRKCA	intron
17	7	rs7784776	G/A	0.43	0.39	0.07	1.42×10−8	0.0	0.36	0.015	1.28×10−9	-	-	IGFBP3	intergenic
18	1	rs4074536	C/T	0.29	−0.42	0.07	2.36×10−8	0.5	-	-	2.36×10−8	-	-	CASQ2	missense
19	13	rs1886512	A/T	0.37	−0.40	0.07	4.31×10−8	0.0	-0.28	0.047	1.27×10−8	-	-	KLF12	intron
20	3	rs2242285	A/G	0.42	0.37	0.07	4.79×10−8	35.4	0.29	0.040	1.09×10−8	-	-	LRIG1/SLC25A26	intron
21	10	rs1733724	A/G	0.25	0.49	0.09	1.26×10−7	0.0	0.34	0.035	3.05×10−8	-	-	DKK1	intergenic
22	17	rs17608766	C/T	0.16	0.53	0.10	3.71×10−7	13.8	0.92	4.7×10−5	4.75×10−10	-	-	GOSR2	intron, 3′

In each locus at least one marker exceeds the genome-wide significance threshold of P < 5 × 10⁻⁸. At locus 1, six signals were identified (r²<0.05) that exceeded genome-wide threshold. In a multiSNP model that included all 6 SNPs, there was evidence that at least 4 of these SNPs were independently associated with QRS duration. The bolded allele is the coded allele. Beta values (β) estimate the difference in QRS interval in milliseconds per copy of the coded allele, adjusted for the covariates in the model. Chr, chromosome; AF, coded allele frequency; SE, standard error; GC, genomic control adjusted; UTR, untranslated region. AF is an average weighted by study size.