Table 2.
Proteins significantly changing in Alzheimer's disease (AD)1
| Spectral Counts |
||||||||
|---|---|---|---|---|---|---|---|---|
| NCBI Reference | Gene ID | Description | MW | TP | % Cov. | CTL | AD | p -value |
| NP_001116539.1 | MAPT | microtubule-associated protein tau | 43 | 12 | 26 | 2 | 55 | 5.88E-15 |
| NP_001157570.1 | VCAN | versican core protein | 182 | 13 | 8 | 95 | 43 | 6.98E-07 |
| NP_000436.2 | PLEC | plectin-1 | 518 | 60 | 18 | 38 | 85 | 6.62E-05 |
| NP_000005.2 | A2M | alpha-2-macroglobulin | 163 | 25 | 26 | 47 | 19 | 0.0001 |
| NP_006588.1 | HSPA8 | heat shock cognate 71 kDa protein | 71 | 19 | 40 | 51 | 97 | 0.0005 |
| NP_001814.2 | CKB | creatine kinase B-type | 43 | 28 | 68 | 123 | 193 | 0.0007 |
| NP_004172.2 | UCHL1 | ubiquitin carboxyl-terminal hydrolase isozyme L1 | 25 | 5 | 32 | 8 | 27 | 0.0015 |
| NP_002645.3 | PKM2 | pyruvate kinase isozymes M1/M2 | 58 | 22 | 53 | 76 | 47 | 0.0022 |
| NP_031381.2 | HSP90AB1 | heat shock protein HSP 90-beta | 83 | 17 | 32 | 25 | 53 | 0.0031 |
| NP_002071.2 | GOT2 | aspartate aminotransferase, mitochondrial | 47 | 8 | 22 | 13 | 3 | 0.0056 |
| NP_003276.3 | TNR | tenascin-R | 149 | 20 | 21 | 56 | 34 | 0.0069 |
| NP_001027392.1 | STXBP1 | syntaxin-binding protein 1 (Munc-18) | 68 | 28 | 55 | 60 | 98 | 0.0080 |
| NP_002777.1 | PSMA1 | proteasome subunit alpha type-1 | 30 | 7 | 40 | 10 | 2 | 0.0104 |
1
MW= molecular weight (kDa), TP = Total peptides identified in control (CTL) and AD; % Cov. = % protein sequence coverage