Table 3 . Summary of PCP defects in the eye and wing of candidate genes studied.

DrosDel deficiency	Gene/RNAi transf. ID	Vertebrate homolog, molecular signature	sev-GAL4	dpp-GAL4	en-GAL4	ap-GAL4
Df(1)ED7161	CG15730/19583	Mks1, Basal body component	Rota, chir, notches, hair oria	NE	NE	Mch
Df(1)ED7161	CG42251/29634	SH3/SH2 adaptor activity	Rota, chirb	NE	Vein defectsc	NE
Df(2L)ED62	CG2863 (Nle)/33574	Regulator of Notch pathway, WD40 repeats	NE	Lethal	Lethal	Mch
Df(2L)ED793	CG15283/ 28550	—	Rota, chirb	Hair oric	Hair oric	NE
Df(2L)ED793	CG15284 (pburs)/27141/2	insect spec. partner of bursicone, ligand for G prot. coupled rec.	Chird	Mch	Mch	Mchc
Df(2L)ED1315	CG31687/21393	APC8 paralog, component of the APC/C	Rota, chir	Mch	Hair ori	Mchc
Df(3L)ED201	CG7004 (fwd)/27785/6	PI4 kinase β	Rota, chird	Lethal	Lethal/notchese	Mchf
Df(3L)ED230	CG11438 (PAP2)/11438	PAP2 type phosphatase	Rota, chirc	ND	ND	Veinc
Df(3L)ED230	CG11426 (PAP2)/11426	PAP2 type phosphatase	NE	ND	ND	Mchc
Df(3R)ED7665	CG1019 (Mlp84B)/18594	CSRP1, LIM domains	Loss, rota, chirbd	NE	NE	NE
Df(3R)ED7665	CG10068/15948	—	Chird	NE	Mch	NE
Df(3R)ED10639	CG6963 (gish)/26003	Casein kinase1 gamma	Loss, rotaf	Mchc	Mchf	ND
Df(2L)ED623	CG13388 (Akap200)/5647	AKAP200/MESR2, protein kinase A binding	Loss, chir	NE	Vein defectsd	NE

The first two columns list the deficiency and gene/RNAi. Third column indicates potential vertebrate homologs and/or molecular function. Further columns indicate which GAL4 driver caused phenotypes. Rota, ommatidial rotation defects; chir, ommatidial chirality defects; hair ori, wing hair orientation defects; mch, multiple cellular hairs; NE, no effect; ND, not done.

^aIncreased copy number 19° escapers.

^bIncreased copy number 29°.

^c29°.

^dWith UAS-dcr2.

^eEscapers with a 25°–18° temperature shift.

^fUAS-dcr2 at 29°.