Skip to main content
. 2012 May;191(1):195–213. doi: 10.1534/genetics.111.137521

Table 3. Average estimates of δ in a half-sib family from a homo-heterozygote sire (family size = 36 or 500) with simulated fT=0.5 and fM=0.5 and varying linkage disequilibrium (δ).

Estimation method
HS ES MIH
Family size:
Simulated δ 36 500 36 500 E(ES) 36 500
0.000 0.001 0.000 0.000 0.000 0.000 0.001 0.000
0.025 0.025 0.025 0.017 0.018 0.013 0.025 0.025
0.050 0.049 0.050 0.034 0.036 0.025 0.050 0.050
0.075 0.074 0.075 0.049 0.051 0.038 0.074 0.075
0.100 0.098 0.100 0.063 0.064 0.050 0.098 0.100
0.125 0.122 0.125 0.075 0.077 0.063 0.122 0.125
0.150 0.146 0.150 0.087 0.088 0.075 0.146 0.150
0.175 0.170 0.175 0.097 0.098 0.087 0.170 0.175
0.200 0.195 0.200 0.106 0.107 0.100 0.194 0.200
0.225 0.218 0.225 0.115 0.116 0.113 0.218 0.225
0.250 0.243 0.250 0.123 0.125 0.125 0.249 0.250

The number of replicates was 104. HS, Average estimates using the method derived for half-sibs in this article. ES, Average estimates over replicates of linkage disequilibrium using the algorithm of Excoffier and Slatkin (1995). E(ES), Predicted LD using the method of not family structure using the algorithm of Excoffier and Slatkin (1995). MIH, Method of maternal informative haplotypes.