Figure 8 .

Loss of CGI121 function bypasses null mutations in CDC13 and telomerase. (A) Comparison of colony sizes of CGI121 and cgi121-Δ isogenic strains propagated at the indicated temperatures. (B) Comparison of the senescence phenotypes of 26 tlc1-Δ CGI121 isolates with 22 tlc1-Δ cgi121-Δ isolates at 32° and 36°, analyzed as in Figure 2B. (C) Three colonies each of cdc13-Δ cgi121-Δ rad24-Δ and CDC13 cgi121-Δ rad24-Δ generated following dissection of the appropriate heterozygous diploid strain at 23°; see Figure S6 for the relative growth of these two strains at 30° and 36°.