Table 1.
Demographic and clinical features of patients and healthy participants
| Variable | Initial Sample Cohort | Disease Controls | Validation Sample Cohort | ||||
|---|---|---|---|---|---|---|---|
| IgAN | Healthy Participants | MPGN-I | FSGS | HSPN | IgAN | Healthy Participants | |
| Participants (n) | 25 | 25 | 3 | 5 | 10 | 50 | 50 |
| Men/women (n/n) | 16∕9 | 15∕10 | 2/1 | 3/2 | 5/5 | 38/12 | 40/10 |
| Age (yr) | 37.2±10.2 | 36.1±10.6 | 35±9.6 | 42±12.3 | 8.5±3 | 36±12.3 | 43±10.6 |
| Serum creatinine (mg/dl) | 0.9±0.2 | 0.8±0.3 | 0.7±0.05 | 0.8±0.4 | 0.5±0.1 | 1.00±0.5 | 0.9±0.3 |
| Estimate GFR (ml/min per 1.73 m2) | 118±22.3 | 106±13.1 | 122±10 | 116.8±11 | ND | 120±11 | 114±12.3 |
| Proteinuria (g/24 h) | 0.3±0.1 | 0.1±0.2 | 2.7±1.2 | 2.05±0.9 | ND | 0.8±0.2 | 0.06±0.02 |
| Systolic BP (mmHg) | 121±20.4 | 120±10 | 133±11.5 | 126±15 | 118±16 | 124±13.3 | 119±9 |
| Diastolic BP (mmHg) | 72±9 | 74±8 | 80±0.5 | 79±6.5 | 67±8 | 77.2±9.7 | 74±9 |
| Total IgA (ng/μl) | 0.10±0.004 | 0.12±0.01 | ND | ND | 0.15±0.01 | 0.14±0.002 | 0.13±0.001 |
Unless otherwise noted, values are expressed as mean ± SD. IgAN, IgA nephropathy; MPGN-I, membranoproliferative GN type I; FSGS, focal segmental glomerulosclerosis; HSPN, Henoch-Schönlein purpura nephritis; ND, not determined.