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. Author manuscript; available in PMC: 2012 Apr 27.
Published in final edited form as: Pediatr Res. 2012 Feb 15;71(4 Pt 1):316–323. doi: 10.1038/pr.2011.78

Figure 4.

Figure 4

Effects of budesonide (BUD) at various concentrations on the molecular organization and lateral structure of Curosurf films. For ease of comparison, the first column repeats AFM topographic images of pure Curosurf at five characteristic surface pressures (π)—20, 30, 40, 50, and 60 mN/m—as shown in the first column of Figure 3. Columns 2–4 show AFM topographic images of Curosurf mixed with 0.1%, 1.0%, and 10% BUD, respectively. Curosurf + BUD films were compared with pure Curosurf at identical π in each row. Langmuir-Blodgett film transfer failed for Curosurf mixed with 10% BUD at 60 mN/m. The AFM scan area was 50 × 50 µm for all images (bar = 10 µm). The full z-range was set to be 5 nm for monolayers (i.e., π ≤ 40 mN/m) and 20 nm for multilayers (i.e., π > 40 mN/m). Characteristic relative heights of multilayers are indicated by arrows. AFM, atomic force microscopy.