Blood flow analysis in hind limb in diabetic and control mice. A: Blood flow was measured with MoorLDI-Laser in all groups before surgery, just after surgery and once a week for 7 weeks (n = 10). B: Quantitative data of blood flow measurements with MoorLDI-Laser in all groups, (n = 10); *P < 0.05 for diabetic versus control, †P < 0.05 for diabetic treated with U0126 versus diabetic mice, and ‡P < 0.05 statistically significant between diabetic versus diabetic treated with AG1478. Red arrow represents macrophages. C: Quantitative data of blood flow analysis in hind limb of nontreated control mice and control mice injected with EGF or with EGF + U0126, (n = 5); *P < 0.05 indicating a significant difference between control treated with EGF + U0126 versus control treated with EGF, †P < 0.05 for nontreated control versus control treated with EGF.