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. 2012 Jan;180(1):209–220. doi: 10.1016/j.ajpath.2011.09.041

Figure 2.

Figure 2

Inflammatory cell infiltrate and corneal haze in Mafia control (nondimerized; no macrophage depletion) and Mafia-treated (dimerized; macrophage depletion) mice 24 hours after corneal CpG-ODN. In vivo epifluorescence image of a Mafia control mouse eye containing extensive eGFP+ inflammatory macrophages in the central cornea (inset) and iris/anterior chamber (A) compared with a Mafia-treated eye that has fewer eGFP+ inflammatory cells (B). The dashed line demarcates the limbus (cornea-scleral junction), and arrows outline the pupil margin of the underlying iris. CpG-ODN increased corneal haze (C) in Mafia control corneas compared with Mafia-treated corneas. An abrogated neutrophil response in Mafia-treated corneas compared with Mafia control corneas 24 hours after CpG-ODN treatment is shown (D). CpG-ODN induced neutrophil and macrophage infiltration into the corneas of bone marrow chimeric mice (E and F) (n = 3 to 6 mice per group). Data are given as mean ± SEM. ns, not significant. *P < 0.05, **P < 0.01, and ***P < 0.001.