Figure 4.

Targeted overexpression of catalase to mitochondria decreases intestinal polyposis in APC^Min/+ mice. Total polyp numbers in small intestine (A) and colon (B) from 20-week-old male mice (APC^Min/+ n = 11, and APC^Min/+ MCAT n = 9). Each point in the graph indicates the total polyp number from one mouse. C: Polyp number in the proximal, middle, and distal small intestine is shown. D: Polyp number in the small intestine as a function of size is shown. C and D: White bars indicate APC^Min/+ and gray bars indicate APC^Min/+ MCAT. The mean ± SD are plotted. *P < 0.05.