Table 1.

Responses of 65 Mice that Underwent TLR4 Transplantation and Were Given LPS or Saline Vehicle Control at 18 Hours after Injection

	TLR4+/+ mice		Marrow TLR4−/− mice		Parenchymal TLR4−/− mice		TLR4−/− mice
Variable	LPS	Saline	LPS	Saline	LPS	Saline	LPS	Saline
Total	8	7	11	5	12	6	10	6
LPS-induced systemic inflammation⁎	7	0	9	0	1	0	0	0
<32°C (no./total assessed)†	3/4	0/4	7/9	0/3	1/5	0/5	0/2	0/2
Weight loss (g)‡	2.0 ± 0.1	0.9 ± 0.3	1.7 ± 0.2	0.0 ± 0.3	2.0 ± 0.2	0.0 ± 0.2	0.8 ± 0.3	0.6 ± 0.3

^⁎Assessed by blinded animal technician based on published description of murine LPS-induced systemic inflammation.⁴

^†Rectal temperature assessed before anesthesia administration and completed for the last subsets of mice in this experiment.

^‡Expressed as mean ± SE.