Table 2.
Summary of Experimental Results for LPS-Induced Systemic Inflammation in Mice that Underwent TLR4 Transplantation
| Variable | TLR4+/+ mice | Marrow TLR4−/− mice | Parenchymal TLR4−/− mice | TLR4−/− mice |
|---|---|---|---|---|
| Systemic inflammation and mortality | X | X | ||
| Early cytokines | ||||
| TNF-α, IL-6, MIP-1α | X | X | ||
| KC, IP-10 | X | X | X | |
| MCP-1 | X | X | ||
| Early neutropenia | X | X | ||
| Weight loss | X | X | X | |
| Late cytokines | X | |||
| Late neutrophilia | X | X | X | |
| Organ MPO | ||||
| Lung, kidney | X | X | ||
| Liver | X | X | X |
The blank spaces in this table (e.g., under TLR4-/- mice column) indicate no difference compared with saline control mice.
X, differences compared with saline control mice.