Table 5.
Sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) of microscopy and RDTs versus PCR (reference method) in high- and low-transmission areas in Madagascar, 2008-2010
| Global | Methods | |
|---|---|---|
| Microscopy | RDT | |
| Sensitivity (95% CI) | 72.7 (67.0-77.9) | 61.8 (54.0-69.1 |
| Specificity (95% CI) | 100.0 (98.5-100.0 | 95.0 (75.1-99.9) |
| PPV (95% CI) | 100.0 (98.1-100.0) | 99.0 (94.9-100.0) |
| NPV (95% CI) | 77.7 (72.8-82.1) | 99.0 (94.9-100.0) |
| High transmission | Methods | |
| Microscopy | RDT | |
| Sensitivity (95% CI) | 70.1 (63.8-75.9) | 60.0 (51.7-67.9) |
| Specificity (95% CI) | 100.0 (97.9-100.0) | 100.0 (81.5-100.0 |
| PPV (95% CI) | 100.0 (97.8-100.0) | 100.0 (96.0-100) |
| NPV (95% CI) | 71.9 (65.9-77.4) | 23.1 (14.3-34.0 |
| -Low transmission | Methods | |
| Microscopy | RDT | |
| Sensitivity (95% CI) | 89.2 (74.6-97.0) | 75.0 (50.9-91.3) |
| Specificity (95% CI) | 100.0 (95.4-100.0 | 50.0 (1.3-98.7) |
| PPV (95% CI) | 100.0 (89.4-100.0) | 93.7 (69.8-99.8) |
| NPV (95% CI) | 100.0 (89.4-100.0) | 16.7 (0.4-64.1) |