Figure 4. Subcellular localization types of the signature proteins.
The images were obtained by immunohistochemical staining of airways and fallopian tubes with protein-specific antibodies in the Protein Atlas project [31]. The antibodies were targeted at the following proteins: (A) C11orf66 (a protein with unknown function), (B) FOXJ1 (a transcription factor known to regulate cilium biogenesis), (C) TSGA10 (a sperm tail protein), (D) RBKS (ribokinase, a ribose metabolism enzyme). Brown corresponds to the antibody-based staining, blue – to staining of nuclei with DAPI. Note that in airways ciliated cells form a continuous layer, while in fallopian tubes they are separated from each other by non-ciliated epithelial cells.