Table 1. Values of the echocardiographic parameters at baseline and two week post-TAC.
| Male | Female | |||||
| Baseline | TAC | CAST | CAST+TAC | Baseline | TAC | |
| Gradient (mmHg) | 4.6±1.2 | 48.0±8.2+++ | 3.5±2.9 | 47.1±3.9+++ | 2.5±1.5 | 56.5±4.5+++ |
| Frequency (b.p.m.) | 435±12 | 435±25 | 444±14 | 444±20 | 442±14 | 437±19 |
| IVST (mm) | 0.68±0.05 | 0.89±0.03++ | 0.66±0.03 | 0.78±0.05 | 0.62±0.02 | 0.84±0.08++ |
| PWT (mm) | 0.67±0.03 | 0.84±0.05++ | 0.68±0.03 | 0.78±0.06 | 0.66±0.03 | 0.89±0.07++ |
| LVEDd (mm) | 4.0±0.1 | 4.3±0.2 | 3.6±0.1$ | 3.8±0.2$ | 3.8±0.1 | 3.8±0.1** |
| LVESd (mm) | 2.7±0.06 | 3.4±0.3+++ | 2.1±0.1$$ | 2.6±0.2+$$ | 2.5±0.1 | 2.4±0.2*** |
| LVM-Echo (mg) | 74.5±4.4 | 123.2±15.9+++ | 59.3±3.6 | 84.6±9.6+$ | 64.0±3.1 | 95.4±8.1+ |
| LVM-Grav (mg) | 91.2±4.7a | 115.0±4.9++ | 65.3±3.2a | 84.7±5.8+$$ | 70.6±3.2a | 90.5±4.2++ ** |
| LVMI-Grav (mg/g) | 3.4±0.20a | 4.3±0.1+++ | 2.8±0.21a | 3.7±0.2++$$ | 3.0±0.1a | 3.8±0.3++ |
| BW (mg) | 27.1±0.9 | 26.7±0.6 | 23.7±1.3 | 25.9±0.6 | 23.5±1.0 | 23.8±1.0 |
IVST: interventricular septum thickness; LVPWT: left ventricular posterior wall thickness; LVEDd: left ventricular end diastolic dimension; LVESd: left ventricular end systolic dimension; LVM-Echo: left ventricular mass by echocardiography; LVM-Grav: left ventricular mass by gravimetry; LVMI-Grav: gravimetric left ventricular mass indexed to the body weight; BW: Body weight. Values are mean ± SEM. a: Values from independent groups of mice killed at baseline.
+
p<0.05,
++
p<0.01,
+++
p<0.001, TAC vs baseline;
*
p<0.05,
**
p<0.01,
***
p<0.001, male vs female;
$
p<0.05,
$$
p<0.01, castrated vs intact (Bonferroni post hoc test).