Table 6. Grade 5 toxicity reported in the literature following stereotactic body radiotherapy for centrally located lung cancer.

Study	Dose fractionation schedule linked to fatal complications	Cause of death	Incidence of death (%)
Timmerman et al7 & Fakiris et al8	20 Gy×3 Fr†; 22 Gy×3 Fr	Pneumonia, hemoptysis, or respiratory failure	4/22 (18.2%)
Song et al10	12 Gy×4 Fr	Hemoptysis	1/9 (11.1%)
Oshiro et al20 *	25 Gy×1 Fr	Hemoptysis	1/21 (4.8%)
Peulen et al21 *	11 Gy×3 Fr; 8 Gy×5 Fr; 15 Gy×3 Fr	Hemoptysis	3/11 (27.3%)
Milano et al22 *	4 Gy×12 Fr; 5 Gy×10 Fr	Hemoptysis, severe dyspnea, or bronchitis	4/53 (7.5%)
Stauder et al23	12 Gy×4 Fr	Bronchial obstruction	1/47 (2.1%)

^†Fr: fractions;

^*previously irradiated patients.