Table 4. Baseline predictors of improvement of the Cognitive Impairment Index (CII) and of the Fatigue Severity Scale (FSS) at 1 year of NTZ treatment: multivariate logistic regression analysis.

Parameter	Baseline	OR	95%Confidence	p value
	Variable		Interval
Improvement of CII	Constant	2.492		0.719
at year 1 (n = 100)	Sex	1.367	(0.399–4.688)	0.619
	Age	0.957	(0.894–1.025)	0.210
	Disease Duration	0.991	(0.913–1.077)	0.834
	Educational School level	1.217	(1.008–1.468)	0.041
	EDSS	0.984	(0.559–1.733)	0.956
	FSS score	0.844	(0.571–1.248)	0.396
	BDI score	1.021	(0.940–1.110)	0.621
	Time from the last steroid
	Pulse	0.974	(0.760–1.250)	0.840
	ARR	0.736	(0.385–1.405)	0.352
Improvement of FSS	Constant	4.140		0.518
at year 1 (n = 100)	Sex	1.029	(0.317–2.865)	0.956
	Age	0.973	(0.917–1.032)	0.359
	Disease Duration	1.012	(0.940–1.090)	0.748
	Educational School level	0.966	(0.821–1.135)	0.672
	EDSS	0.848	(0.524–1.374)	0.504
	BDI score	1.028	(0.956–1.105)	0.460
	CII	0.974	(0.904–1.049)	0.487
	Time from the last steroid
	Pulse	1.000	(0.820–1.220)	0.998
	ARR	0.948	(0.502–1.790)	0.869

Abbreviations: ARR = Annualized Relapse Rate; EDSS = Expanded Disability Status Scale; BDI = Beck Depression Inventory.