Table 5. Changes of mean scores for each cognitive test after 1 and 2 years of NTZ treatment.
| 1 year Treatment (n = 100) | 2 years Treatment (n = 53) | ||||
| Baseline | Year 1 | Baseline | Year 1 | Year 2 | |
| Verbal | |||||
| Memory | |||||
| SRT-LTS | 35.20 (13.90) | 36.68 (13.58) | 35.49 (14.10) | 37.94 (13.94) | 36.64 (15.09) |
| SRT-CTLR | 26.83 (14.60) | 26.67 (14.87) | 28.15 (14.63) | 28.32 (15.58) | 28.24 (16.65) |
| SRT-D | 7.11 (2.65) | 7.54 (3.62) | 7.13 (2.55) | 7.98 (4.41) | 7.34 (3.93) |
| Spatial | |||||
| Memory | |||||
| SPART | 17.65 (6.14) | 18.90 (6.04)* | 18.58 (6.36) | 18.40 (6.47) | 19.68 (5.99) |
| SPART-D | 6.30 (3.48) | 6.51 (2.55) | 6.85 (4.10) | 6.66 (2.56) | 6.60 (2.17) |
| Attention | |||||
| SDMT | 42.87 (12.33) | 46.29 (12.44)** | 43.32 (12.99) | 48.06 (12.09) | 49.57 (12.92)† |
| PASAT-3 | 34.01 (14.02) | 34.24 (14.94) | 35.75 (14.53) | 36.34 (14.80) | 38.88 (14.46)† |
| PASAT-2 | 25.61 (12.81) | 28.09 (12.85)* | 26.94 (14.25) | 31.03 (13.12) | 32.45 (13.59)† |
| Executive | |||||
| Function | |||||
| WLG | 19.98 (6.02) | 20.48 (5.79) | 20.81 (5.66) | 20.41 (5.42) | 22.15 (5.48) |
| ST | 70.90 (15.18) | 69.98 (18.45) | 69.35 (13.70) | 69.40 (13.27) | 65.42 (14.30) |
*
p<0.05 (Wilcoxon signed-rank test);
**
p<0.0001 (Wilcoxon signed-rank test);
†
p<0.01 (Friedman two-way test);
Abbreviations: SRT-LTS = Selective Reminding Test – Long-Term Storage; SRT-CTLR = Selective Reminding Test – Consistent Long-Term Retrieval; SRT-D = Selective Reminding Test –Delayed; SPART = 10/36 Spatial Recall Test; SPART-D = 10/36 Spatial Recall Test-Delayed; SDMT = Symbol Digit Modalities Test; PASAT 3 = Paced Auditory Serial Addition Test three second rate; PASAT 2 = Paced Auditory Serial Addition Test two second rate; WLG = Word List Generation; ST = Stroop Test.
Values are expressed as Mean (SD).