Table 6. Association of abnormal anal cytology and HPV genotypes among study participants.
Anal infection of 26 HPV types | Abnormal/Normal | Adjusted OR* (95% CI) | ASCUS/Normal | Adjusted OR* (95% CI) | (ASIL/ASC-H)/Normal | Adjusted OR* (95% CI) |
High-Risk types infection | ||||||
Negative for high-risk types | 10/26 | Ref. | 6/26 | Ref. | 4/26 | Ref. |
Positive for high-risk types | 26/29 | 2.02 (0.77–5.29) | 13/29 | 1.63 (0.49–5.43) | 13/29 | 2.48 (0.68–9.00) |
p for difference | 0.15 | 0.43 | 0.17 | |||
By multiplicity of HPV types | ||||||
0 | 8/19 | Ref. | 5/19 | Ref. | 3/19 | Ref. |
1 | 12/25 | 1.22 (0.40–3.72) | 6/25 | 0.83 (0.20–3.41) | 6/25 | 1.71 (0.36–8.02) |
2 | 9/7 | 3.81 (1.00–14.61) | 5/7 | 4.08 (0.79–21.11) | 4/7 | 4.71 (0.77–28.61) |
≥3 | 7/4 | 4.71 (1.02–21.76) | 3/4 | 2.71(0.41–17.82) | 4/4 | 7.49 (1.07–52.21) |
p for trend | 0.04 | 0.20 | 0.04 |
Abbreviation: ASCUS = atypical squamous cells of undetermined significance; ASC-H = atypical squamous cells but cannot exclude HSIL; ASIL = anal squamous intraepithelial lesions, include low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL); CI = confidence intervals; HPV = human papillomavirus; OR = odds ratio.
Adjusted for age, education, age at the first homosexual act, frequency of homosexual behaviors in the past 6 months and ever found sexual partners in gay venues.