Figure 4. Treatment with mNPC significantly increased the density of the granule cells and decreased their diameter.

A. There was no difference in the density of granule cells between disomic and trisomic mice overall. However, treatment with mNPC significantly increased the density of the granule cells (p<0.05). While this effect is more clearly observable in the disomic/NPC group (#), the interaction between treatment and karyotype suggests that mNPC effect was present in both karyotypes. B. Animals implanted with mNPC had granule cells with significantly smaller cell soma than untreated or saline treated animals (p<0.05). Again, this is best observed in the disomic group (#) although statistically both mNPC groups were affected. Mean ± SEM shown.