Figure 6. Trisomic pups were delayed in DMs and did not improve with treatment.

A, B. Righting response (A) and the cliff avoidance (B) were delayed in trisomic pups and this delay was not altered by the implantation of saline or mNPC. C. Trisomic pups were also delayed in negative geotaxis. While trisomic pups were unaffected by treatment, the implantation of mNPC significantly delayed disomic pups to a degree that was comparable to the significant delays observed in the trisomic pups. D. Trisomic pups were delayed in time to ear canal opening. Treatment with both mNPC produced a delay in ear opening compared to untreated pups, while treatment with saline produced a significant additional delay. There was no interaction effect, indicating that both karyotypes were affected in a similar manner. * A significant main effect of karyotype indicates that overall trisomic pups were delayed compared to disomics. ∧ Indicates a significant delay due to the main effect of treatment regardless of karyotype (post hoc p<0.05). ‘n’ is the total number of pups in each group. Average day of achievement ± SEM shown.