Figure 7. The peak power of the membrane potential oscillation was sensitive to modulation of I_A and I_T and activation of PKA.

Power spectra of MPOs in BLA PNs in response to a depolarizing step with artificial IPSPs, with mean (solid lines) and 95% confidence intervals (shaded region). Frequencies at which the 95% confidence intervals do not overlap indicate statistically significant differences among the plots. (A) In the presence of TTX, neurons exhibit a weak MPO. (B,C) MPOs were not enhanced by bath application of 100 µM 4-AP (B) but were significantly enhanced by 500 µM 4-AP, with peak power at 4.9 Hz (C). (D) Application of forksolin, an activator of the c-AMP cascade, at 10 µM also enhanced a MPO with peak power at 4.8 Hz. (E) The MPO was significantly enhanced by a combination of 500 µM 4-AP and 10 µM forskolin, with peak power greater than for either drug alone but occurring at a similar frequency. (F) The MPO observed in forskolin and 4-AP was completely abolished by co-application of NiCl (500 µM) to block low-threshold calcium channels.