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. 2012 Apr 26;7(4):e35320. doi: 10.1371/journal.pone.0035320

Figure 9. Membrane potential oscillations in the BLA were bi-directionally modulated by the adenylyl cyclase signaling cascade.

Figure 9

Cumulative power spectra of intrinsic theta frequency MPOs in BLA principal neurons. Responses are plotted as mean (solid lines) and 95% confidence intervals (shaded regions). Frequencies at which the 95% confidence intervals do not overlap indicate statistically significant differences among the plots. (A) BAPTA-containing patch solutions disorganized the frequency tuning of 4-AP- and forskolin-induced MPOs. (B) Inhibiting PKA activation completely abolishes forskolin-induced MPOs. (C) Activation of PKA with the cAMP analog 8Br-cAMP induces MPOs in TTX alone that are similar to those observed in response to forskolin. (D) Activation of mGluR II glutamate receptors with LY379268 completely blocked 4-AP and forskolin-induced theta MPOs.